The change of numbers of AV lesions before and after treatment within the same group was analyzed by paired t-test and the comparison between group at the end of study was performed with unpaired t-test. In accordance with predilection of acne, the number of lesions was divided into 3 different areas that are face, upper chest and back. The proportions of subjects, who met the success rate definition in each group, were analyzed by chi-square test.