The blooming blueberry industry has produced large amount of blueberry-leaf wastes. Therefore, it is necessary to convert this waste into higher added-value products. Several studies have shown that blueberry leaves are important sources of polyphenols including phenolic acids and flavonoids and possessed potential antioxidant capacity [5]. Moreover, both yield and biological activity of the plant extracts are highly related to the extraction solvents employed [6,7,8]. It has been reported the characteristics of the extraction solvents noticeably affect the total phenolic content (±25% variation) and antioxidant activity (up to 30% variation) of the plant extracts [9]. The ethanolic extracts of rabbiteye blueberry leaves contained higher total phenolic content and total flavonoid content, and had higher antioxidant activity than that in blueberry fruits [10]. And the water extracts of blueberry leaf infusions had significant reduced capacity and radical scavenging potential [11].