We also found that inhibition of the cell surface GRP78 increased E-Cadherin expression and decreased N-Cadherin
level. On the contrary, forced expression of the cell surface GRP78 increased N-Cadherin expression and decreased E-Cadherin
level, suggesting that the cell surface GRP78 plays critical role in the regulation of EMT process. These findings suggest that the
cell surface GRP78 plays a stimulatory role in the invasion process and may be a potential anti-invasion target for the treatment of
hepatocellular carcinoma.