Micro coulometric titration in a liquid drop with electrochemical generation for iodine was proposed as an approach for
downscaling analysis. Thiosulfate and ascorbic acid were chosen to
be models to test the performance of the proposed systems. This
system is simple and cost effective. It consumes very low sample
and reagent(s) volumes, in microliter levels, with a simple falling
drop phenomenon. This simple manipulation of liquid drop on a
slope hydrophobic path by gravity provides a novel analytical
system that is similar to aflow system but without tubing. The
proposed system should be useful to various applications such as
the total antioxidant compound determination in human serum
which needs a low volume of sample solution[31,32], gas
sampling interface on liquid drop[30]. Further development with
some other types of detection and to provide higher degrees of
automation has been in progress