High-density lipoprotein transports cholesterol from peripheral tissues to the liver and transfers cholesterol to LDL. While in the serum, the free cholesterols in HDL are converted to cholesteryl esters. these esterified cholesterols are delivered to the liver for synthesis of bile acids and steroid hormones. The choiesterol uptake from HDL differs from that noted with LDL. This process does not involve endocytosis and degradation of the lipopertein particle. Instead, in a selective lipid uptake, the HDL binds to the liver cell surface and transfers its cholesteryl ester to the cell. The HDL, depleted from its lipid content, then reenters the circulation. It is desirable to have a high level of HDL in the blood because of the way it removes cholesterol from the bloodstream.