Hydroxylation of lysine and prolineamino acids occurs inside the lumen. This process is dependent on ascorbic acid (Vitamin C) as a cofactor. Further glycosylationof specific hydroxylysineresidues occurs.
Triple helical structure is formed inside the endoplasmic reticulum from each two alpha-1 chains and one alpha-2 chain. This is called procollagen.
Procollagenis transported into the golgiapparatus, where it is packaged and secreted by exocytosis.
PMT321_