Psidium guajava L. (guava) is widely used in traditional medicine for the treatment of diarrhea, gastroenteritis
and as anti-inflammatory, among other uses. This research evaluated the antimicrobial
and antioxidant activities of spray dried extracts from leaves of Psidium guajava L. (SDGEs). Different
technological adjuvants, namely: maltodextrin (MD), colloidal silicon dioxide (A), arabic gum (E) and -
cyclodextrin (CD) at concentration of 8% (wet base) were added to drying composition. SDGEs were
characterized through determination of the total phenolic and flavonoid content. The extracts were
tested against fungi (Candida albicans, Candida krusei and Candida glabrata), Gram-positive bacteria
(Staphylococcus aureus) and Gram-negative bacteria (Escherichia coli and Pseudomonas aeruginosa) by
the microdilution assay. The antioxidant activity of the SDGEs was assessed by the DPPH protocol. The
results showed that the MDEA and CD SDGEs were more effective against C. glabrata (MIC = 80 g/mL),
followed by MA SDGE which exhibited activity against C. krusei and C. glabrata also (MIC = 100 g/mL).
The better inhibitory effect on S. aureus was observed to the MA SDGE with a value of 100 g/mL. The
IC50 of the SDGEs ranged from 7.96 to 8.11 g/mL by DPPH• method. The results indicates significant
antimicrobial and antioxidant activities of Psidium guajava SDGEs presenting high potential as an active
phytopharmaceutical ingredient for development of herbal medicines.
© 20
Psidium guajava L. (guava) is widely used in traditional medicine for the treatment of diarrhea, gastroenteritisand as anti-inflammatory, among other uses. This research evaluated the antimicrobialand antioxidant activities of spray dried extracts from leaves of Psidium guajava L. (SDGEs). Differenttechnological adjuvants, namely: maltodextrin (MD), colloidal silicon dioxide (A), arabic gum (E) and -cyclodextrin (CD) at concentration of 8% (wet base) were added to drying composition. SDGEs werecharacterized through determination of the total phenolic and flavonoid content. The extracts weretested against fungi (Candida albicans, Candida krusei and Candida glabrata), Gram-positive bacteria(Staphylococcus aureus) and Gram-negative bacteria (Escherichia coli and Pseudomonas aeruginosa) bythe microdilution assay. The antioxidant activity of the SDGEs was assessed by the DPPH protocol. Theresults showed that the MDEA and CD SDGEs were more effective against C. glabrata (MIC = 80 g/mL),followed by MA SDGE which exhibited activity against C. krusei and C. glabrata also (MIC = 100 g/mL).The better inhibitory effect on S. aureus was observed to the MA SDGE with a value of 100 g/mL. TheIC50 of the SDGEs ranged from 7.96 to 8.11 g/mL by DPPH• method. The results indicates significantantimicrobial and antioxidant activities of Psidium guajava SDGEs presenting high potential as an activephytopharmaceutical ingredient for development of herbal medicines.© 20
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