In this work, conductive nanosilver ink was used as a case study to evaluate the efficacy of the framework discussed above. Both the as-supplied ink and printed material were fully characterized and, after being determined to merit nano-specific scrutiny, the printed material was subjected to submersion tests with and without UV light exposure to evaluate the potential for AgNP release. Since the release potential of a printed circuit during actual use is low, these tests were designed to roughly approximate the environmental exposure from a scenario in which an end-user disposes of a printed circuit. Since this case study is intended to evaluate and demonstrate the decision framework presented in et al. rather than perform a thorough risk assessment, simulated circuits were simply submerged and shaken in water as opposed to more complicated testing that would more closely simulate rainfall or exposure to other natural waters. The potential for environmental persistence and toxicity (using the standard freshwater model Ceriodaphnia dubia) were then determined for both the as-supplied ink and the released material. Although more testing would be necessary to perform a true risk assessment of the entire life cycle of the technology, the results presented here demonstrate the applicability and utility of our tier-based approach toward normal use scenarios.