Lactobacillus plantarum (L. plantarum) is a rod-shaped, gram-positive lactic acid bacterium. It is commonly found in the human and other mammalian gastrointestinal tracts, saliva, and various food products. It can grow at temperatures between 15-45˚C and at pH levels as low as 3.2 [1]. L. plantarum is a facultative heterofermentative [2,3] that ferments sugars to produce lactic acid, ethanol or acetic acid, and carbon dioxide under certain conditions and selective substrates. Depending on the carbon source, these bacteria can switch from using heterofermentative and homofermentative ways of metabolism. This bacterium is acid and bile salt tolerant, which allows it to survive the passage through the gastrointestinal tract of humans. L. plantarum is of current interest to researchers and the food industry since it is considered a safe probiotic. It can help limit the amount of pathogenic bacteria or diseases that can have a negative impact on humans. In addition, recent research indicates that L. plantarum can be used as a vaccine vehicle.