Phytase, myo-inositol hexakisphosphate phosphohydrolase (EC 3.1.3.8), was first reported in 1907 by Suzuki and coworkers. However, the enzyme’s potential to solve an important practical problem, i.e., degrade phytate in foodstuffs was recognized as early as in the 1960s [1]. Phytate when present in foodstuffs abundantly had long been recognized as anti nutrient because it can bind divalent cations and peptides, thereby interfering with the mineral nutrition in monogastric animals, including poultry and hog [2] and [3]. To complicate the matter, undigested phytate in poultry and hog manure has the potential to foul up the environment when naturally occurring microbes hydrolyze phytate to release inorganic orthophosphate into the groundwater. Harmful algal bloom (HAB) in the Chesapeake Bay followed by a fish killed in the 1990s had drawn attention from environmentalists [4]. The need for phytase supplementation of the poultry and hog feed was offered as a possible solution to cut down phosphate pollution of America’s waterways [5].