Carbon metabolism
Abundances of all proteins in the ethanol utilization pathway were significantly increased in response to low growth rates (Supplementary Fig. S6 and Fig. 4). In contrast, only a few proteins from other catabolic pathways, such as acetate-, pyruvate-, butyrate-, benzoate-, phenol-, p-cresol-, and p-hydroxybutyrate-degrading pathways, significantly increased in abundance under carbon limitation (Fig. 4). The highest-fold change among catabolic proteins (up to 1470) at low compared to high growth rates was observed for the two proteins of ethanol degradation: the iron-containing ethanol dehydrogenase (Gmet 1046) and the tungsten-containingaldehyde ferredoxin oxidoreductase (Gmet 1045) (SupplementaryTables S2 and S3).