The origins of Osotspa date to 1891. The business grew, and acknowledging their success, the family received from King Vajiravudh the honorary family name "Osathanugrah". The business is still family-owned.
After World War II the business continued to grow. The company name was changed to "Osotspa Co., Ltd.". In 1959, King Rama IX granted a royal warrant to the company, giving it permission to use the royal Garuda emblem. In 1965 the company began to import Lipovitan-D ("Lipo") energy drink from Japan's Taisho Pharmaceutical Company. Despite being classified as a pharmaceutical, it became very popular among working men. In 1969 Osotspa began to manufacture the product under license from Taisho Pharmaceutical.