Laccases (EC 1.10.3.2) are multi-copper polyphenol oxidases produced by fungi, bacteria, and plants. These enzymes are involved in the formation of plant cell wall by catalyzing the polymerization of monolignols to lignin through the generation of free radical via Cu2+-mediated single-electron transfer [1]. Contrary to plants, fungi and bacteria use laccases to mineralize recalcitrant lignin in dead wood making the microbial laccases key players in recycling of carbon-based materials in nature. In addition, laccases have attracted agreat deal of attention in biotechnological applications due to their high catalytic activity toward a broad range of aromatic substrates.