Figure 4.The damage caused to the alveoli as a result of COPD
is markedly increased in many COPD sub - jects. Pepe et al. (1982) found the ability to exhale may become, insuf cient and the residual inward elastic recoil creates a posi - tive pressure. To the alveoli (known as intrinsic positive end-expiratory pressure (PEEP) or auto-PEEP).Auto-PEEP represents the incomplete emptying of the lungs caused by air ow obstruction which results, in hyper-in ation. Of the lungs (Petrof, et al 1990). This has been found to be a common feature observed in stable COPD subjects (Soares et. Al, the 2008).
Patients who have no respiratory Compro - mise naturally produce a PEEP between 2 - 3 cmH20.Therefore a patient with lung disease requires and produces auto-PEEP to enable the alveoli to stay open allowing for,, A more effective exchange of, gases (Lumb 2000). This insuf ciency affects the workload of breathing which then becomes. More dif -
cult causing the, diaphragm and intercostal muscles to tire easily. Emphysema and chron - ic bronchitis can occur. Simultaneously.But one may be more prominent than the other; this is dependent on pulmonary function, tests (Clausen 1990).
Although this. Debilitating disease mainly affects, the lungs it has been found to affect the body as a whole. This can create systemic. Consequences including skeletal, muscle dys - function nutritional abnormalities weight loss,,,, cardiovascular abnormalitiesAnd nerv - ous system abnormalities (Andreassen and Vestbo 2003;,, Agusti 2005). The sensation of dyspnoea which causes,, Panic, and anxiety has been suggested to cause cognitive and emotional effects impairing quality, of life (,) Kelly 2007.
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