Cisplatin is notably emetic. Dexamethasone is effective; also Lorazepam, which gives useful amnesia although sedation and dysphoria are dose-limiting. The observation that dexamethasone and lorazepam together were more efficacious than either on its own (synergism) led to the testing of other combinations, including the addition of metoclopramide in high dose. All three drugs have been used together for the most emetogenic cytotoxic regimens.
Cisplatin