This paper is mainly based on analysis of the data and information collected primarily from the
government institutions and their publications. Because this paper has a need for additional data, the
authors visited parts from the analyzed areas for detailed preparation of the work materials and also
registered the problems in relation with the pollution of the surface waters in the analyzed area. The main
source of data for the quantity of used water for technological applications also the quantities of
wastewaters from industry and mining is the State statistical office in the Republic of Macedonia. Further,
the data for wastewaters from the households are received from the Ministry of environment and physical
planning of the Republic of Macedonia. The data for the concentrations of the previously defined
parameters in terms of the pollution of the major water flows are received from the State statistical office
and the Ministry of environment and physical planning in the Republic of Macedonia. Because this paper
is directed toward presenting the condition and trend of pollution of the major water flows, many
different statistical methods have been used for its processing, such as: method of analysis, method of
synthesis, comparative method, and the method of field observation has been used.