The sciatic nerve injury (SNI) model induces symptoms of neuropathic pain such as mechanical allodynia. The SNI mouse model involves ligation of two of the three branches of the sciatic nerve (the tibial nerve and the common peroneal nerve), while the sural nerve is left intact. The lesion results in marked hypersensitivity in the lateral area of the paw, which is innervated by the spread sural nerve.