The irritating effects of nicotinate were ameliorated by
long-term intake of either flaxseed or borage oil (Table 5).
Reddening of the skin after the chemical challenge was
lower in both groups after 6 and 12 weeks of intervention.
Similar effects have been described after intake of longchain
n-3 fatty acids(5). Supplementation with dietary fish oil
diminished UV-B erythemal sensitivity in man. Although the
mechanism of protection is not clear, it has been speculated
that interferences with inflammatory pathways are important.
In this context it is interesting to note that in the present
study both supplements were active, although cutaneous
blood flow was more affected by flaxseed oil. Therefore, it
might be speculated that the contribution of PUFA on membrane
and cell structure is at least in part responsible for the
prevention of exogenous damage