CFP relaxed the intact aorta ring preparations in a dose dependent manner. This effect was almost abolished in the endotheliumdenuded preparations and partially blocked in the intact rings treated with L-NAME, but it was not modified by indomethacin (see
Fig. 1 ). As expected, in the in vivo experiments, the SHR that only
received water or saline did not modify their SBP. On the contrary,
CFP caused a significant decrease in SBP. L-NAME caused a slight
increase in SBP in the rats, and the effect of CFP was not observed
in the SHR that were treated with L-NAME (see Fig. 2). Nevertheless, indomethacin treatment did not modify SBP in the SHR and
this drug failed also to modify the antihypertensive effect of CFP
in these animals (see Fig. 3).
CFP relaxed the intact aorta ring preparations in a dose dependent manner. This effect was almost abolished in the endotheliumdenuded preparations and partially blocked in the intact rings treated with L-NAME, but it was not modified by indomethacin (seeFig. 1 ). As expected, in the in vivo experiments, the SHR that onlyreceived water or saline did not modify their SBP. On the contrary,CFP caused a significant decrease in SBP. L-NAME caused a slightincrease in SBP in the rats, and the effect of CFP was not observedin the SHR that were treated with L-NAME (see Fig. 2). Nevertheless, indomethacin treatment did not modify SBP in the SHR andthis drug failed also to modify the antihypertensive effect of CFPin these animals (see Fig. 3).
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