It has been reported that calcium glycerophosphate (CaGP) reduces the acid dissolution of enamel7. This has led to its addition into toothpastes which improved their cariostatic effects5,14. The cariostatic properties of CaGP have been demonstrated in various in vivo and in vitro studies. Several mechanisms have been suggested, including plaque-pH buffering, increase of plaque calcium and phosphate levels and direct interaction with dental mineral12. However, to the best of our knowledge, there is no information in the literature regarding the supplementation of soft drinks with CaGP aiming to reduce their erosive potential. Considering that CaGP contains both calcium and phosphate, the aim of the present study was to evaluate if the supplementation of Coca-ColaTM and Sprite ZeroTM with different concentrations of CaGP would be able to reduce the erosive potential of these soft drinks.