Secondary Outcome Measures
Activities limitation resulting from breathlessness was
assessed by patients selecting the statement from the
modified British Medical Research Council questionnaire
that best described their limitation. Healthrelated
quality of life was assessed using the St
George’s Respiratory Questionnaire (SGRQ), and a
change of 4 units was considered clinically relevant. 13
Quadriceps muscle strength was assessed using the
10-RM with ankle weights. Exercise tolerance was
measured using the 6MWT. Two tests were performed
and the best performance was recorded.