Our results show that Wolbachia inhibits viral replication and dissemination in the main
dengue vector,Aedes aegypti. Moreover, the virus transmission potential of Wolbachia-infectedAe. aegypti was significantly
diminished when compared to wild-type mosquitoes that did not harbor Wolbachia. At 14 days post-infection, Wolbachia
completely blocked dengue transmission in at least 37.5% ofAe. aegyptimosquitoes. We also observed that this Wolbachia mediated viral interference was associated with an elevated basal immunity and increased longevity in the mosquitoes.
These results underscore the potential usefulness of Wolbachia-based control strategies for population replacement.