After week 28 of the study, female mice exposed
to 1,000 mg/kg d-limonene daily decreased in
mean body weight by 5-15 percent compared to their
respective vehicle controls.15 Increased incidence of
multinucleated hepatocytes and cytomegaly was observed
in male but not female mice. As a result of the
presence of liver lesions, a “No Observed Adverse Event
Level” (NOAEL) dosage of 250 mg/kg/day and a “Lowest
Observed Adverse Event Level” (LOAEL) dosage of
500 mg/kg/day was calculated