Similar findings also were observed in a case-control
study of adults aged 65 years or older at a rural community
hospital in Ohio (USA) during 2004 and 2006. The authors
of this study explored the risk for pneumonia as cause of
hospitalization with the use of atypical antipsychotics and
other non-neuropsychiatric drug classes that were suspected
to be possible risk factors for CAP [11]. As compared to
patients unexposed to study drugs, users of atypical
antipsychotics were associated with a significant increase
in the risk for CAP (adj. OR: 2.26; 95% CI: 1.23–4.15).
Interestingly, the same findings were observed in the
study by Star et al. [12], which used a completely different
methodology. These authors applied the pattern-discovery
method for longitudinal patient records on the UK IMS
Health Disease Analyzer dataset as of January 1, 2006 [12].
The method contrasted the observed rate of registration of
pneumonia-related International Classification of Diseases
(ICD)-10 terms in various time periods relative to the
prescription of atypical and typical antipsychotics, to the
overall registration rate of the same medical event, relative