In the present study, the risk factors associated with total blood loss were blood loss before second-line therapy, fibrinogen levels, and time elapsed before application of second-line therapy. The time elapsed before second-line therapy began was negatively correlated with fibrinogen levels; therefore, prompt treatment should be administered at the onset of PPH. The longer the time interval from onset of PPH to insertion of the tamponade will result in greater blood loss and decreased fibrinogen levels. When the fibrinogen levels cannot be recovered by infusion, DIC may occur.