is
the conversion of DHO to orotate. DODH is thought to catalyze
this reaction (Jones, 1980). DODH was found to be
located on the outer surface of the inner membrane of
mitochondria in mammals (Jones, 1980). Although there
are no detailed studies of a similar enzyme in plants,
Miersch et al. (1986) suggested that tomato DODH is also
located in mitochondria.