Ethnopharmacological relevance: Polygonum multiflorum has traditionally been used for treating patients
suffering from baldness and hair loss in East Asia.
Aimof the study: The present study sought to investigate the hair growth promoting activities of Polygonum
multiflorum and its mechanism of action.
Materials and methods: The Polygonum multiflorum extract was topically applied to the shaved dorsal
skin of telogenic C57BL6/N mice. To determine the effect of Polygonum multiflorum extract in telogen
to anagen transition, the expression of -catenin and Sonic hedgehog (Shh) was determined by
immunohistochemistry analysis.
Results: Polygonum multiflorum extract promoted hair growth by inducing anagen phase in telogenic
C57BL6/N mice. In Polygonum multiflorum extract treated group, we observed increase in the number and
the size of hair follicles that are considered as evidence for anagen phase induction. Immunohistochemical
analysis revealed that earlier induction of -catenin and Shh were observed in Polygonum multiflorum
extract treated group compared to that in control group.
Conclusion: These results suggest that Polygonum multiflorum extract promotes hair growth by inducing
anagen phase in resting hair follicles.