The oxidative stress biomarkers, lipid hydroperoxide and malondialdehyde, from lipid peroxidation process in patients with type 2 diabetic patients were increased compared with healthy control. This results indicated that patients with type 2 diabetes mellitus had increased oxidative stress status and total antioxidant capacity in type 2 diabetic patients were decreased this may be cause by the counter action for the oxidative stress in type 2 diabetic patients. The oxidative stress biomarker (lipid hydroperoxide and malondialdehyde) and total antioxidant capacity were used as biomarkers for prognosticate in the development of atherosclerosis and/or cardiovascular complication in diabetic patients.