A meta‑analysis from Germany retrieved 198 studies (covering 22,238 patients) that report 218 treatment‑control comparisons. Significant small‑to‑medium effects were observed for individual and group psychotherapy and psychoeducation. These effects were sustained, in part, in the medium term (≤6 months) and long‑term (>6 months). Short‑term effects were evident for relaxation training. Studies that pre‑selected participants according to increased distress produced large effects at post‑treatment. A moderator effect was found for the moderator variable “duration of the intervention,” with longer interventions producing more sustained effects. Indicators of study quality were often not reported. Small‑sample bias indicative of possible publication bias was found for some effects, particularly with individual psychotherapy and relaxation training.[25] This randomized controlled trial has used precaution (ample sample size, blinding, long follow‑up, identified indicators) to address caution under this met analysis..