The liquid suppositories were prepared by cold
method. The drug and various amounts of excipients
except poloxamer 407 were completely dispersed in
distilled water with continuous agitation at room
temperature. The mixtures were then cooled to 40C.
Then poloxamer 407 was added slowly with continuous
stirring. The dispersions were then stored in a refrigerator
at 40C overnight. The composition of various prepared
formulations is given in table