: The purpose of this work is to investigate in a quantitative manner, the gross and regional
structural patterns in cartilage and bone from the humeral head of end-stage OA patients, with the goal
of identifying patterns of disease. Since the prevalence of primary OA of the shoulder is increasing as the
population ages and the non-traumatic degenerative changes leading to this disease are poorly understood,
a site-specific morphometric analysis speaks to the structure-function remodelling relationship of
the pathological anatomy