Sawangjaroen et al. showed the anti-amoebic [6] and anti-giardial [7] activities of P. betle used
by AIDS patients. In addition to these bioactivities of P. betle, its antibacterial activities have
likewise been extensively demonstrated in many studies [8–15]. Shitut et al. showed that the
ethanol and ethyl acetate extracts of four varieties of P. betle tested had significant activities
against Vibrio cholerae ogawa, Staphylococcus aureus and Streptococcus pneumoniae, while the
hexane and benzene extracts produced moderate activities