Methodology: Health and Safety management in research laboratory has been developed according to the standard practice. To evaluate the implementation of the Health and Safety management in research laboratory, 7 pilot research laboratories in department of Pilot plant development and training institute. The safety checklist is used to find the hazard in laboratory in 8 areas that are (1) Working Area Setting (2) Electric System (3) Facilities Care (4) Ventilation (5) Fume Hood (6) Chemical and Waste Storage (7) MSDS (8) Safety Preparation. Assessment evaluation has been done on 7 pilot research laboratories by the Safety Committee and Safety management division, Energy Environment Safety and Health Office.