The tetrameric structure was generated by crystallographic
symmetry to verify the relative position of the IAA molecule in
relation to the biological assembly of ConM. IAA molecules were
positioned in the central cavity. The structural IAAs were positioned
in a face-to-face arrangement relative to the indole group. Stacking
hydrophobic interactions between the IAA rings stabilized the
tetrameric form of ConM (Fig. 4). The amino acids that stabilize the
hydrophobic pocket are Ser108, Ser110, Val129, Asn131, Thr194,
and Thr196.