Schizophrenia and bipolar disorder are among chronic diseases which cause deterioration in patients, affect both patients and their environment negatively by this deterioration and have a remitting/relapsing course. Disruption of treatment and consequent need to continue treatment in an inpatient setting and its cost on country economy are other issues to be discussed. For this reason, there is ongoing research about every step (etiological factors, clinical findings, assessment of clinical symptoms, factors affecting treatment, prognosis and factors affecting prognosis) of these diseases. We investigated the caregiver burden at relatives of patients with schizophrenia and bipolar disorder by Zarit Burden Interview.