Pathophysiology
The pathophysiology of asthma is complex and involves the following components:
•Airway inflammation: The mechanism of inflammation in asthma may be acute, subacute, or chronic, and the presence of airway edema and mucus secretion also contributes to airflow obstruction and bronchial reactivity.
•Intermittent airflow obstruction: Airflow obstruction can be caused by a variety of changes, including acute bronchoconstriction, airway edema, chronic mucous plug formation, and airway remodeling.
•Bronchial hyper-responsiveness: To compensate airflow obstruction and increased demand for oxygen, lungs get hyperinflated. This compensatory hyperinflation with vasoconstriction leads to uneven distribution of air and change in airflow resistance thus resulting in aleveolar hypoventilation and effectively causing alveolar hypoxia
PathophysiologyThe pathophysiology of asthma is complex and involves the following components:•Airway inflammation: The mechanism of inflammation in asthma may be acute, subacute, or chronic, and the presence of airway edema and mucus secretion also contributes to airflow obstruction and bronchial reactivity.•Intermittent airflow obstruction: Airflow obstruction can be caused by a variety of changes, including acute bronchoconstriction, airway edema, chronic mucous plug formation, and airway remodeling.•Bronchial hyper-responsiveness: To compensate airflow obstruction and increased demand for oxygen, lungs get hyperinflated. This compensatory hyperinflation with vasoconstriction leads to uneven distribution of air and change in airflow resistance thus resulting in aleveolar hypoventilation and effectively causing alveolar hypoxia
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