In 1988, Prof. Zografi re-viewed the critical aspects of water–solid interactions from a
fundamental, scientific perspective, highlighting the distinction between adsorption in crystalline and absorption in amorphous solids, capillary condensation, deliquescence, and formation of hydrates—physicochemical factors that continue to
challenge the development of drug products 25 years later.
In 1988, Prof. Zografi re-viewed the critical aspects of water–solid interactions from a
fundamental, scientific perspective, highlighting the distinction between adsorption in crystalline and absorption in amorphous solids, capillary condensation, deliquescence, and formation of hydrates—physicochemical factors that continue to
challenge the development of drug products 25 years later.
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