Objectives: This guideline provides recommendations for the diagnosis
and management of suspected cow’s-milk protein allergy (CMPA) in
Europe. It presents a practical approach with a diagnostic algorithm and
is based on recently published evidence-based guidelines on CMPA.
Diagnosis: If CMPA is suspected by history and examination, then strict
allergen avoidance is initiated. In certain circumstances (eg, a clear history
of immediate symptoms, a life-threatening reaction with a positive test
for CMP–specific IgE), the diagnosis can be made without a milk challenge.
In all other circumstances, a controlled oral food challenge (open or blind)
under medical supervision is required to confirm or exclude the diagnosis
of CMPA.