Optical coherence tomography (OCT), a non-MRI
imaging tool, is a noninvasive method to observe and
quantify the retinal nerve fiber layer thickness. The
retinal nerve is unmyelinated; thus, OCT is able to
quantify axonal integrity and damage. Gordon-Lipkin
and colleagues showed that OCT correlated with brain
atrophy in MS (Gordon-Lipkin et al., 2007). This imaging
tool may be an important outcome measurement
in clinical trials of neuroprotection because it
provides information about axonal integrity.