GSH is a true protagonist in the fascinating drama of cell regulation. All the aspects outlined above (summarized in a graphic form in Fig. 1) should be carefully evaluated, when considering the participation of GSH in primary cellular processes such as gene expression, cell proliferation or apoptosis [20], [44] and [45]. Is it to be expected that even more faces, more roles of GSH may emerge from future research? At least one novel, redox-unrelated aspect was recently described and deserves quotation here: it has been reported that binding sites provided with true specificity for GSH exist in the central nervous system, and this satisfies the main requisite for considering GSH as a neuromediator [46]. Indeed, the significance of GSH and reactions related to its transport and metabolism—after decades of fruitful research—still holds aspects to investigate, plots to unveil.