It is not yet know whether cloner will develop and age normally or whether subtle failures in genomic reprogramming or genetic imprinting might lead to various defects theortically tissues generated from cells cloned from a patient's own adult nucleus should not trigger an immune response but it is possible that subtle difference caused by theforeign cytoplasm in the donor egg might cause a rejection response although scientists at Duke univerity suggested that human clones might not experience the problem sencountered in cloned animals the risk remains very high and quite unpredictable Scientists generally agree that human reproductive cloning should not be permitted before the scientific and technical issues have been clarified