We have determined the DNA sequence of the long unique region (UL) in the
genome of herpes simplex virus type 1 (HSV-1) strain 17. The UL sequence contained
107943 residues and had a base composition of 66-9~ G+C. Together with our
previous work, this completes the sequence of HSV-1 DNA, giving a total genome
length of 152260 residues of base composition 68.3~ G+C. Genes in the UL region
were located by the use of published mapping analyses, transcript structures and
sequence data, and by examination of DNA sequence characteristics. Fifty-six genes
were identified, accounting for most of the sequence. Some 28 of these are at present of
unknown function. The gene layout for UL was found to be very similar to that for the
corresponding part of the genome of varicella-zoster virus, the only other completely
sequenced alphaherpesvirus, and the amino acid sequences of equivalent proteins
showed a range of similarities. In the whole genome of HSV-1 we now recognize 72
genes which encode 70 distinct proteins.
We have determined the DNA sequence of the long unique region (UL) in the
genome of herpes simplex virus type 1 (HSV-1) strain 17. The UL sequence contained
107943 residues and had a base composition of 66-9~ G+C. Together with our
previous work, this completes the sequence of HSV-1 DNA, giving a total genome
length of 152260 residues of base composition 68.3~ G+C. Genes in the UL region
were located by the use of published mapping analyses, transcript structures and
sequence data, and by examination of DNA sequence characteristics. Fifty-six genes
were identified, accounting for most of the sequence. Some 28 of these are at present of
unknown function. The gene layout for UL was found to be very similar to that for the
corresponding part of the genome of varicella-zoster virus, the only other completely
sequenced alphaherpesvirus, and the amino acid sequences of equivalent proteins
showed a range of similarities. In the whole genome of HSV-1 we now recognize 72
genes which encode 70 distinct proteins.
การแปล กรุณารอสักครู่..
