Abstract. Urinary oxalate is an important determinant of calcium
oxalate kidney stone formation. High doses of vitamin B6
may decrease oxalate production, whereas vitamin C can be
metabolized to oxalate. This study was conducted to examine
the association between the intakes of vitamins B6 and C and
risk of kidney stone formation in women. The relation between
the intake of vitamins B6 and C and the risk of symptomatic
kidney stones were prospectively studied in a cohort of 85,557
women with no history of kidney stones. Semiquantitative
food-frequency questionnaires were used to assess vitamin
consumption from both foods and supplements. A total of 1078
incident cases of kidney stones was documented during the
14-yr follow-up period. A high intake of vitamin B6 was
inversely associated with risk of stone formation. After adjusting
for other dietary factors, the relative risk of incident stone
formation for women in the highest category of B6 intake ($40
mg/d) compared with the lowest category (,3 mg/d) was 0.66
(95% confidence interval, 0.44 to 0.98). In contrast, vitamin C
intake was not associated with risk. The multivariate relative
risk for women in the highest category of vitamin C intake
($1500 mg/d) compared with the lowest category (,250
mg/d) was 1.06 (95% confidence interval, 0.69 to 1.64). Large
doses of vitamin B6 may reduce the risk of kidney stone
formation in women. Routine restriction of vitamin C to prevent
stone formation appears unwarranted.
Abstract. Urinary oxalate is an important determinant of calciumoxalate kidney stone formation. High doses of vitamin B6may decrease oxalate production, whereas vitamin C can bemetabolized to oxalate. This study was conducted to examinethe association between the intakes of vitamins B6 and C andrisk of kidney stone formation in women. The relation betweenthe intake of vitamins B6 and C and the risk of symptomatickidney stones were prospectively studied in a cohort of 85,557women with no history of kidney stones. Semiquantitativefood-frequency questionnaires were used to assess vitaminconsumption from both foods and supplements. A total of 1078incident cases of kidney stones was documented during the14-yr follow-up period. A high intake of vitamin B6 wasinversely associated with risk of stone formation. After adjustingfor other dietary factors, the relative risk of incident stoneformation for women in the highest category of B6 intake ($40mg/d) compared with the lowest category (,3 mg/d) was 0.66(95% confidence interval, 0.44 to 0.98). In contrast, vitamin Cintake was not associated with risk. The multivariate relativerisk for women in the highest category of vitamin C intake($1500 mg/d) compared with the lowest category (,250mg/d) was 1.06 (95% confidence interval, 0.69 to 1.64). Largedoses of vitamin B6 may reduce the risk of kidney stoneformation in women. Routine restriction of vitamin C to preventstone formation appears unwarranted.
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