Another approach was the design of “peptide-amphiphile”
triple helices, based on the non-covalent self-assembly of lipophilic
molecules, N-terminally-linked to a peptide sequence
. Both the covalent branch and “peptide-amphiphile”
approaches have been used for studying susceptibility of
triple-helical peptides toMMPhydrolysis and localization of
enzyme cleavage sites, with Edman degradation sequence
analysis and MALDI-MS