There was some reduction in all subjects for TC and
LDL-C from screening to baseline during the 4-week
TLC diet lead-in (Fig. 2). By week 2 after randomization,
there was a significant lowering of TC, LDL-C, and
Apo-B in subjects taking pantethine as compared with
placebo; this was sustained up to the end of the active
study period (16 weeks). However, the magnitude of the
LDL-C reduction in the pantethine group was greatest at
week 2 (7%), drifting to a total of 4% reduction at week
16. It was observed (Fig. 2) that there was a trend toward
higher LDL-C in both the pantethine and placebo groups
from weeks 2 to 16 with values being maintained at a