Decreased serum albumin, due to illness or decreased
protein synthesis (due to ageing), potentiates the
response to drugs that bind to albumin by increasing the
free-drug fraction in the acute condition. Therefore, drug
levels or response correlation could be altered and this
needs to be considered when interpreting drug levels
especially during long-term usage. An elevated level of
the acute phase reactant α1
-acid glycoprotein, due to
ageing or disease, increases the binding of basic drugs,
such as lignocaine, which in turn decreases the drug
response.
Decreased serum albumin, due to illness or decreasedprotein synthesis (due to ageing), potentiates theresponse to drugs that bind to albumin by increasing thefree-drug fraction in the acute condition. Therefore, druglevels or response correlation could be altered and thisneeds to be considered when interpreting drug levelsespecially during long-term usage. An elevated level ofthe acute phase reactant α1-acid glycoprotein, due toageing or disease, increases the binding of basic drugs,such as lignocaine, which in turn decreases the drugresponse.
การแปล กรุณารอสักครู่..
