A comprehensive literature search was performed using a pre-defined, written protocol of The Cochrane Database, CINAHL,
PubMed, and Scopus databases
with no start date to January
2015. The search criteria, devel-oped with the help of a medi-cal librarian, used the following
Medical Subject Headings terms:
1. Septic shock OR Severe sep-sis OR Sepsis AND
2. Antibacterial agents OR
Antibiotics