Ischaemic stroke is the result of a transient or permanent reduction of blood flow restricted to the territory of a cerebral artery and is typically caused by an embolic or thrombotic event or cerebral small vessel disease, i.e. in-situ-thrombosis and hyalinosis of small intracerebral arteries and arterioles. Hemodynamic (“watershed”) infarctions as a result of high-grade stenoses of extra- or intracerebral arteries are comparatively rare (less than 5%)2.