t
Interestingly, the prostate cancer cell lines analyzed in this study differed
in their GSH content and GST activity [39]. Given the major differences observed between cell lines derived from the same cancer of origin, it is clear that each respective cell type will have varying levels of
detoxification machinery and, thus, differences in their susceptibility to lipid electrophile exposure. This could especially be true when considering the responsiveness of primary cells versus immortalized cell lines with respect to HNE cytotoxicity.