The works of Metchnikoff and Tissier were the first to make scientific suggestions
concerning the probiotic use of bacteria, even if the word "probiotic" was not coined until
1960, to name substances produced by microorganisms which promoted the growth of
other microorganisms (Lilly and Stillwell, 1965). Fuller (1989), in order to point out the
microbial nature of probiotics, redefined the word as "A live microbial feed supplement
which beneficially affects the host animal by improving its intestinal balance". A similar
definition was proposed by Havenaar and Huis in 't Veld (1992), “a viable mono or mixed
culture of bacteria which, when applied to animal or man, beneficially affects the host by
improving the properties of the indigenous flora”. A more recent, but probably not the last
definition is "live microorganisms, which when consumed in adequate amounts, confer a
health effect on the host" (Guarner and Schaafsma, 1998).
The works of Metchnikoff and Tissier were the first to make scientific suggestionsconcerning the probiotic use of bacteria, even if the word "probiotic" was not coined until1960, to name substances produced by microorganisms which promoted the growth ofother microorganisms (Lilly and Stillwell, 1965). Fuller (1989), in order to point out themicrobial nature of probiotics, redefined the word as "A live microbial feed supplementwhich beneficially affects the host animal by improving its intestinal balance". A similardefinition was proposed by Havenaar and Huis in 't Veld (1992), “a viable mono or mixedculture of bacteria which, when applied to animal or man, beneficially affects the host byimproving the properties of the indigenous flora”. A more recent, but probably not the lastdefinition is "live microorganisms, which when consumed in adequate amounts, confer ahealth effect on the host" (Guarner and Schaafsma, 1998).
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